Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling

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• 作者：So-Young Hwang¹ ; Xianming Deng² ; Sanguine Byun¹ ; Chan Lee¹ ; Seung-Joo Lee³ ; Hyunsuk Suh³ ; Jianming Zhang¹ ; Qiaofeng Kang² ; Ting Zhang² ; Kenneth D. Westover⁴ ; Anna Mandinova¹ ; ⁵ ; ^{amandinova@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Sam W. Lee¹ ; ⁵ ; ^{swlee@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：28 June 2016
• 年：2016
• 卷：16
• 期：1
• 页码：28-36
• 全文大小：2784 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">MSAB, a β-catenin inhibitor, was identified using cell-based chemical screening

dd><dt class="label">•dt><dd>

d="p0015">MSAB inhibits growth of Wnt/β-catenin-dependent cancer cells in vitro and in vivo

dd><dt class="label">•dt><dd>

d="p0020">MSAB disrupts β-catenin activity by prompting proteasomal degradation of β-catenin

dd><dt class="label">•dt><dd>

d="p0025">MSAB binds to β-catenin

dd>dl>