The neuronal extracellular matrix restricts distribution and internalization of aggregated Tau-protein
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- 作者：A. Suttkus ; anne.suttkus@medizin.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; M. Holzer ; M. Morawski ; T. Arendt
- 关键词：AD ; Alzheimer&rsquo ; s disease ; CSP ; chondroitin sulfate proteoglycans ; ECM ; extracellular matrix ; ECS ; extracellular space ; EDTA ; ethylenediaminetetraacetic acid ; HEPES ; 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid ; HSPGs ; heparan sulfate proteoglycans ; NFT ; neurofibrillary tangles ; PD ; Parkinson&rsquo ; s disease ; PN ; perineuronal net ; WFA ; Wisteria floribunda agglutinin ; WT ; wildtype
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：313
- 期：Complete
- 页码：225-235
- 全文大小：2576 K
文摘
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Distribution of aggregated Tau protein is limited by the neural ECM.
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Aggregated Tau protein is internalized by cells within one hour.
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Internalization of Tau is restricted by the perineuronal nets, a special form of ECM.
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Distribution and internalization of Tau is increased in tissue of ECM-knockout mice.