First and second generation antipsychotics differentially affect structural and functional properties of rat hippocampal neuron synapses
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- 作者：Christine Gottschlinga ; Maren Geisslera ; Gianna Springera ; Rainer Wolfb ; Georg Juckelb ; Andreas Faissnera ; andreas.faissner@rub.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNS ; central nervous system ; DIV ; days in vitro ; DMSO ; dimethylsulfoxide ; E ; embryonic day ; ECM ; extracellular matrix ; EDTA ; Ethylenediaminetetraacetic acid ; FGA ; first-generation antipsychotic ; GFAP ; glial fibrillary acid protein ; MEA ; multielectrode array ; P ; postnatal day ; PBS ; phosphate buffered saline ; PEI ; polyethylenimine ; PFA ; paraformaldehyde ; PNN ; perineuronal net ; SGA ; second-generation antipsychotic ; WFA ; Wisteria floribunda agglutinin
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：19 November 2016
- 年：2016
- 卷：337
- 期：Complete
- 页码：117-130
- 全文大小：4192 K
文摘
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A neuron-glia insert co-culture model was used to monitor synapse plasticity.
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The co-culture serves to model chronic treatment with psychopharmacological drugs.
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Distinct antipsychotics have differential effects on synapse formation.
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Resulting neuronal networks show differences of synaptic activity.