Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway

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• 作者：Yao Wu^a ; ^b ; Hongying Chen^b ; Ruli Li^b ; Xiaoxiao Wang^b ; He Li^a ; Juanjuan Xin^b ; Zhiqiang Liu^b ; Sisi Wu^b ; Wei Jiang^b ; ^{wcumsjw@scu.edu.cn} ; Ling Zhu^a ; ^{zhuling529@163.com}
• 关键词：MAPK ; mitogen-activated protein kinase ; ANP ; atrial natriuretic peptide ; BNP ; brain natriuretic peptide ; 3-MA ; 3-methyladenine ; DMSO ; dimethyl sulfoxide ; WGA ; wheat germ agglutinin
• 刊名：Toxicology Letters
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：264
• 期：Complete
• 页码：87-98
• 全文大小：3631 K
• 卷排序：264

文摘

Cucurbitacin-I, a triterpenoids, has diverse pharmacological and biological activities. Cucurbitacin-I induced cardiotoxicity (hypertrophy and death) in H9c2 cells. Cucurbitacin-I induced strong autophagy, hypertrophy and apoptosis in H9c2 cells. Cucurbitacin-I induced cardiotoxicity via an ERK-autophagy dependent pathway.