Asthma phenotypes in inner-city children

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• 作者：Edward M. Zoratti ; MD^a ; ^{ezoratt1@hfhs.org" class="auth_mail" title="E-mail the corresponding author} ; Rebecca Z. Krouse ; MS^b ; Denise C. Babineau ; PhD ; MS^b ; Jacqueline A. Pongracic ; MD^c ; George T. O'Connor ; MD ; MS^d ; Robert A. Wood ; MD^e ; Gurjit K. Khurana Hershey ; MD ; PhD^f ; Carolyn M. Kercsmar ; MD^f ; Rebecca S. Gruchalla ; MD ; PhD^g ; Meyer Kattan ; MD^h ; Stephen J. Teach ; MD ; MPHⁱ ; Steven M. Sigelman ; RN ; MHA^j ; Peter J. Gergen ; MD ; MPH^j ; Alkis Togias ; MD^j ; Cynthia M. Visness ; PhD^b ; William W. Busse ; MD^k ; Andrew H. Liu ; MD^l ; ^m
• 关键词：Allergen sensitization ; allergy ; airway inflammation ; bronchial hyperresponsiveness ; asthma phenotypes ; asthma severity ; IgE ; hierarchical cluster ; inner-city asthma ; rhinitis
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：138
• 期：4
• 页码：1016-1029
• 全文大小：788 K

文摘

Children with asthma in low-income urban areas have high morbidity. Phenotypic analysis in these children is lacking, but may identify characteristics to inform successful tailored management approaches.

Objective

We sought to identify distinct asthma phenotypes among inner-city children receiving guidelines-based management.

Methods

Nine inner-city asthma consortium centers enrolled 717 children aged 6 to 17 years. Data were collected at baseline and prospectively every 2 months for 1 year. Participants' asthma and rhinitis were optimally managed by study physicians on the basis of guidelines. Cluster analysis using 50 baseline and 12 longitudinal variables was performed in 616 participants completing 4 or more follow-up visits.

Results

Five clusters (designated A through E) were distinguished by indicators of asthma and rhinitis severity, pulmonary physiology, allergy (sensitization and total serum IgE), and allergic inflammation. In comparison to other clusters, cluster A was distinguished by lower allergy/inflammation, minimally symptomatic asthma and rhinitis, and normal pulmonary physiology. Cluster B had highly symptomatic asthma despite high step-level treatment, lower allergy and inflammation, and mildly altered pulmonary physiology. Cluster C had minimally symptomatic asthma and rhinitis, intermediate allergy and inflammation, and mildly impaired pulmonary physiology. Clusters D and E exhibited progressively higher asthma and rhinitis symptoms and allergy/inflammation. Cluster E had the most symptomatic asthma while receiving high step-level treatment and had the highest total serum IgE level (median, 733 kU/L), blood eosinophil count (median, 400 cells/mm³), and allergen sensitizations (15 of 22 tested).

Conclusions

Allergy distinguishes asthma phenotypes in urban children. Severe asthma often coclusters with highly allergic children. However, a symptomatic phenotype with little allergy or allergic inflammation was identified.