Presurgical window of opportunity trial design as a platform for testing anticancer drugs: Pros, cons and a focus on breast cancer
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- 作者：Marcello Maugeri-Saccà ; Dr.a ; b ; 1 ; maugeri@ifo.it" class="auth_mail" title="E-mail the corresponding author ; Maddalena Barba ; Dr.a ; b ; 1 ; maddalena.barba@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Patrizia Vicia ; Laura Pizzutia ; Domenico Sergia ; Teresa Catenaroa ; Luigi Di Lauroa ; Marcella Mottolesec ; Daniele Santinid ; Michele Milellae ; Ruggero De Mariab
- 关键词：Window of opportunity trials ; Cancer therapeutics ; Attrition rate ; Breast cancer
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：106
- 期：Complete
- 页码：132-142
- 全文大小：1316 K
文摘
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Window of opportunity trials (WOTs) envision a short course treatment before surgery.
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WOTs streamline the drug development process by defining target patient population.
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WOTs can provide information about the molecular changes operated by the treatment.
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In recent years presurgical WOTs have been successfully applied to breast cancer.
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WOTs deserve to be deployed on a large scale basis.