Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice
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- 作者：Isabel Gonzá ; lez-Mariscala ; Susan M. Krzysik-Walkera ; Wook Kima ; b ; wookkim21@ajou.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Michael Rousea ; Josephine M. Egana
- 关键词：Adenylyl cyclase ; cAMP ; CB1 ; GLP-1 ; Incretin ; Insulin secretion
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：5 March 2016
- 年：2016
- 卷：423
- 期：Complete
- 页码：1-10
- 全文大小：1290 K
文摘
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CB1−/− mice have improved glucose homeostasis in regular diet and high fat diet.
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Knocking out CB1 increases incretin secretion in mice.
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Cannabinoids inhibit GLP-1R-dependent insulin secretion in insulinoma cells via CB1.
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ACEA inhibition of insulin secretion is rescued by CB1 blockade in human islets.