Abnormal interactions of verbal- and spatial-memory networks in young people at familial high-risk for schizophrenia

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• 作者：Xiaobo Li^a ; ^b ; ^{xli.aecom@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Heidi W. Thermenos^c ; Ziyan Wu^b ; Yoko Momura^d ; Kai Wu^e ; Matcheri Keshavan^f ; ^g ; Lawrence Seidman^f ; ^g ; Lynn E. DeLisi^c ; ^f
• 关键词：Schizophrenia ; Functional MRI ; High-risk ; Language ; Verbal working memory ; Spatial working memory
• 刊名：Schizophrenia Research
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：176
• 期：2-3
• 页码：100-105
• 全文大小：639 K

文摘

Working memory impairment (especially in verbal and spatial domains) is the core neurocognitive impairment in schizophrenia and the familial high-risk (FHR) population. Inconsistent results have been reported in clinical and neuroimaging studies examining the verbal- and spatial-memory deficits in the FHR subjects, due to sample differences and lack of understanding on interactions of the brain regions for processing verbal- and spatial-working memory.

Methods

Functional MRI data acquired during a verbal- vs. spatial-memory task were included from 51 young adults [26 FHR and 25 controls]. Group comparisons were conducted in brain activation patterns responding to 1) verbal-memory condition (A), 2) spatial-memory condition (B), 3) verbal higher than spatial (A–B), 4) spatial higher than verbal (B–A), 5) conjunction of brain regions that were activated during both A and B (A ∧ B). Group difference of the laterality index (LI) in inferior frontal lobe for condition A was also assessed.

Results

Compared to controls, the FHR group exhibited significantly decreased brain activity in left inferior frontal during A, and significantly stronger involvement of ACC, PCC, paracentral gyrus for the contrast of A–B. The LI showed a trend of reduced left-higher-than-right pattern for verbal-memory processing in the HR group.

Conclusions

Our findings suggest that in the entire functional brain network for working-memory processing, verbal information processing associated brain pathways are significantly altered in people at familial high risk for developing schizophrenia. Future studies will need to examine whether these alterations may indicate vulnerability for predicting the onset of Schizophrenia.