Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents
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- 作者：David G. Workman ; Michael Hunter ; Lynn G. Dover ; David Té ; tard ; david.tetard@northumbria.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Siderophore ; Chelator ; Biostatic agent ; Bacterial growth ; 1-Hydroxy-2(1H)-pyridinone
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：49-58
- 全文大小：766 K
文摘
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Novel hexadentate chelators based on 1-hydroxy-2(1H)-pyridinone synthesised.
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First hexadentate chelators based on 1-hydroxy-2(1H)-pyridinone shown to be biostatic.
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Biostatic effect (minimum inhibitory concentration) measured on a range of pathogenic bacteria.
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Biostatic effect compare favourably with that of most powerful Fe(III) chelator known.