Gα12/13 signaling promotes cervical cancer invasion through the RhoA/ROCK-JNK signaling axis
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- 作者：Bo Yuan ; Jinquan Cui ; jinquancuijqc@163.com" class="auth_mail" title="E-mail the corresponding author ; Wuliang Wang ; Kehong Deng
- 关键词：Cervical cancer ; Gα12/13 ; Invasion ; RhoA/ROCK-JNK
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：473
- 期：4
- 页码：1240-1246
- 全文大小：988 K
文摘
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Gα12/Gα13 is upregulated in cervical cancer cell lines.
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Gα12/Gα13 is not involved in cervical cancer cell proliferation.
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Gα12/Gα13 promotes cervical cancer cell invasion.
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The role of Rho G proteins in G12-promoted cervical cancer cell invasion.
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G12 promotes cell invasion through activation of the ROCK-JNK signaling axis.