Niementowski-type synthesis of pyrido[3,2-e][1,2,4]triazines: potent aza-analogs of pyrido[2,3-b]pyrazine fungicides
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- 作者：Patrick J. Crowley ; Clemens Lamberth ; Urs Mü ; ller ; Sebastian Wendeborn ; Olivia-A. Sageot ; John Williams ; Alex ; er Bartovič
- 关键词：Heterocycle ; Triazine ; Pyridotriazine ; Niementowski reaction ; Fungicide
- 刊名：Tetrahedron Letters
- 出版年：2010
- 出版时间：12 May 2010
- 年：2010
- 卷：51
- 期：19
- 页码：2652-2654
- 全文大小：237 K
文摘
Novel trisubstituted pyrido[3,2-e][1,2,4]triazines have been found to possess similar biological activity to the corresponding pyridopyrazine fungicides against important phytopathogens such as Mycosphaerella graminicola (wheat leaf blotch), Magnaporthe grisea (rice blast), and Rhizoctonia solani (rice sheath blight). They have been prepared for the first time from a monocyclic triazine by Niementowski-type ring condensation.