Study on growth hormone treatment in small for gestational age children

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• 作者：Julia Sá ; nchez Zahonero ; ^{ju-san-za@hotmail.com} ; Marí ; a José ; Ló ; pez Garcí ; a
• 关键词：Small for gestational age ; Human growth hormone ; Short stature
• 刊名：Anales de Pediatría (English Edition)
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：86
• 期：2
• 页码：87-93
• 全文大小：620 K
• 卷排序：86

文摘

To analyse the effectiveness of growth hormone (GH) therapy in short-stature children born small for gestational age (SGA) without catch-up growth (height at the beginning of treatment < −2.5 SDS), in Valencia (Spain), between 01/01/2003 and 12/31/2013; and to compare our findings with previously published data.Materials and methodsAnthropometric data from the SGA children were obtained from the database of the “Ministry of Health of Valencia”. These data were retrospectively reviewed.ResultsA total of 115 SGA children, with a mean age of 8.10 ± 2.75 years and height of −3.14 ± 0.59 SDS started treatment (dose: 0.035 ± 0.004 mg/kg/day) between January 1st, 2003 and March 31st, 2013. After 2 years of therapy (n = 115, age: 10.50 ± 2.72 years) the height SDS was −2.11 ± 0.66; and after 4 years (n = 96, age: 12.65 ± 2.46 years) of −1.76 ± 0.75 SDS. This latest improvement in stature matches ages at which the growth spurt usually occurs. Only 35 out of 115 children reached adult height, although impaired (−2.22 ± 0.86 SDS), and failed to achieve their target height (−1.72 ± 0.75 SDS). However, this sub-group grew to near the height of the shorter parent (−1.95 ± 1.28 SDS), and 42.9% of these 35 cases increased their stature by more than 1 SDS.ConclusionsThe studied sample did not achieve satisfactory growth results, as in other published series. Our findings might be improved by starting treatment earlier, and with doses individualised according to patient characteristics.