Polymorphism A1/A2 in the cell surface integrin subunit β3 and disturbance of implantation and placentation in women with recurrent pregnancy loss

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• 作者：Petar D. Ivanov ; Regina S. Komsa-Penkova ; Emiliana I. Konova ; Tsvetomira M. Tsvyatkovska ; Katia S. Kovacheva ; Maria N. Simeonova ; Stoyan Y. Tanchev
• 关键词：Embryonic and fetal recurrent pregnancy loss ; integrin α ; V/&#x3b2 ; integrin α ; IIb/&#x3b2 ; 3 ; polymorphism A1/A2
• 刊名：Fertility and Sterility
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：94
• 期：7
• 页码：2843-2845
• 全文大小：74 K

文摘

Polymorphism A1/A2 in the &#x3b2;3 subunit of integrins αIIb/&#x3b2;3 and αV/&#x3b2;3 is implicated in the risk of development of embryonic and fetal recurrent pregnancy loss (RPL). In 191 women with RPL, polymorphism A1/A2 was statistically significantly associated with RPL at <10 weeks of gestation (29.3 % versus 16.4 % in controls), but it was much more pronounced in 67 women with RPL between 10 and 20 weeks of gestation (41.8 % ), illustrating its role in recurrent fetal loss.