Altered pathogenicity of a tl/CH/LDT3/03 genotype infectious bronchitis coronavirus due to natural recombination in the 5′- 17 kb region of the genome
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- 作者：Zongxi Han ; Tingting Zhang ; Qianqian Xu ; Mengying Gao ; Yuqiu Chen ; Qiuling Wang ; Yan Zhao ; Yuhao Shao ; Huixin Li ; Xiangang Kong ; Shengwang Liu ; swliu@hvri.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Infectious bronchitis coronavirus ; Recombination ; Serotype ; Pathogenicity ; Vaccination-challenge test
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：213
- 期：Complete
- 页码：140-148
- 全文大小：1997 K
文摘
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Recombination accounts for the emergence of IBV variants.
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Strain ck/CH/LGX/130530 is originated from recombination events between a pathogenic tl/CH/LDT3/03- and H120-like strain.
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Recombination event occurred in the 5′ end of the Gene 1 region did not result in changes in the genotype, serotype, and protectotype of the IBV.
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The replicase gene of IBV ck/CH/LGX/130530 isolate is associated with viral pathogenicity.