Recombinant duck enteritis viruses expressing major structural proteins of the infectious bronchitis virus provide protection against infectious bronchitis in chickens
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- 作者：Huixin Lia ; 1 ; Yulong Wanga ; b ; 1 ; Zongxi Hana ; Yu Wanga ; Shulin Lianga ; Lu Jianga ; Yonghao Hub ; Xiangang Konga ; Shengwang Liua ; swliu@hvri.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Infectious bronchitis virus ; Recombinant duck enteritis virus ; Protective efficacy
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：19-26
- 全文大小：1161 K
文摘
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Infectious bronchitis virus (IBV) causes a respiratory disease in domestic chickens worldwide.
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Duck enteritis virus (DEV) was used as viral vaccine vector in chickens.
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Recombinant DEV (rDEV) expressing IBV N, S, or S1 conferred protection against IBV.
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Covalent vaccination with rDEV-N & rDEV-S1 conferred higher level of protection against IBV.