Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling
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- 作者：So-Young Hwang1 ; Xianming Deng2 ; Sanguine Byun1 ; Chan Lee1 ; Seung-Joo Lee3 ; Hyunsuk Suh3 ; Jianming Zhang1 ; Qiaofeng Kang2 ; Ting Zhang2 ; Kenneth D. Westover4 ; Anna Mandinova1 ; 5 ; amandinova@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Sam W. Lee1 ; 5 ; swlee@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：16
- 期：1
- 页码：28-36
- 全文大小：2784 K
文摘
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MSAB, a β-catenin inhibitor, was identified using cell-based chemical screening
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MSAB inhibits growth of Wnt/β-catenin-dependent cancer cells in vitro and in vivo
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MSAB disrupts β-catenin activity by prompting proteasomal degradation of β-catenin
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MSAB binds to β-catenin