Effects of different promoters on the protective efficacy of recombinant Marek’s disease virus type 1 expressing the VP2 gene of infectious bursal disease virus
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- 作者：Kai Li ; Yongzhen Liu ; Changjun Liu ; Li Gao ; Yanping Zhang ; Yulong Gao ; Hongyu Cui ; Xiaole Qi ; Li Zhong ; Xiaomei Wang ; xmw@hvri.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Recombinant MDV1 ; Infectious bursal disease virus ; Promoters ; VP2 protein ; Protective efficacy
- 刊名：Vaccine
- 出版年：2016
- 出版时间：11 November 2016
- 年：2016
- 卷：34
- 期：47
- 页码：5744-5750
- 全文大小：1367 K
文摘
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We constructed two MDV1-based IBDV vaccines using Pec or CMV promoter.
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The rMDV-Pec-VP2 using Pec promoter expressed a larger amount of VP2.
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The rMDV-Pec-VP2 induced stronger antibody response against IBDV in chickens.
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The rMDV-Pec-VP2 provided full protection against vvIBDV challenge in chickens.