Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome
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- 作者：Xiaolei Suna ; b ; Xuefei Jiaoc ; 1 ; Yarong Maa ; Yong Liua ; Lei Zhanga ; Yanzheng Hea ; yzhe1573@163.com" class="auth_mail" title="E-mail the corresponding author ; Yunhui Chend ; yunhuichen520@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Trimethylamine N-oxide ; Oxidative stress ; NLRP3 inflammasome ; Endothelial dysfunction ; Atherosclerosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 December 2016
- 年：2016
- 卷：481
- 期：1-2
- 页码：63-70
- 全文大小：1826 K
文摘
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TMAO triggered ROS and activate TXNIP-NLRP3 inflammasome.
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eNOS/NO were obviously inhibited by TMAO.
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TMAO-mediated abnormities were abrogated by siRNA-TXNIP or NLRP3, especially followed by NAC.