The effect of nonuniform magnetic targeting of intracoronary-delivering mesenchymal stem cells on coronary embolisation
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- 作者：Zheyong Huang ; Yunli Shen ; Ning Pei ; Aijun Sun ; Jianfeng Xu ; Yanan Song ; Gangyong Huang ; Xiaoning Sun ; Shuning Zhang ; Qing Qin ; Hongming Zhu ; Shan Yang ; Xiangdong Yang ; Yunzeng Zou ; Juying Qian ; Junbo Ge
- 关键词：Magnetic targeting ; Stem cell ; Nanoparticle ; Embolisation ; Coronary artery
- 刊名：Biomaterials
- 出版年：2013
- 出版时间：December, 2013
- 年：2013
- 卷：34
- 期：38
- 页码：9905-9916
- 全文大小：5355 K
文摘
Magnetic targeting has been recently introduced to enhance cell retention in animals with acute myocardial infarction. However, it is unclear whether the magnetic accumulation of intravascular cells increases the risk of coronary embolism. Upon finite element analysis, we found that the permanent magnetic field was nonuniform, manifestated as attenuation along the vertical axis and polarisation along the horizontal axis. In the in?vitro experiments, iron-labelled mesenchymal stem cells (MSCs) were accumulated in layers predominantly at the edge of the magnet. In an ischaemic rat model subjected to intracavitary MSCs injection, magnetic targeting induced unfavourable vascular embolisation and an inhomogeneous distribution of the donor cells, which prevented the enhanced cell retention from translating into additional functional benefit. These potential complications of magnetic targeting should be thoroughly investigated and overcome before clinical application.