Wip 1 inhibits intestinal inflammation in inflammatory bowel disease

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• 作者：Qi Zhang^a ; Cuiping Zhang^a ; ^{rose201001@126.com} ; Fangzhi Chang^b ; Kun Liang^a ; Xiaoyan Yin^a ; Xiaoyu Li^a ; Kun Zhao^a ; Qinghui Niu^a ; Zibin Tian^a
• 关键词：Inflammatory bowel disease ; Wip1 ; Neutrophil ; Inflammation ; Migration
• 刊名：Cellular Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：310
• 期：Complete
• 页码：63-70
• 全文大小：1842 K
• 卷排序：310

文摘

Expression of Wip1 was markedly decreased in patients with active IBD. Wip1 was mainly expressed on neutrophils and the expression was regulated by TNF-α. Knock out of Wip1 in mouse aggravated colonic inflammation. Neutrophils migration was increased after knock out of Wip1.