High fat diet exacerbates dextran sulfate sodium induced colitis through disturbing mucosal dendritic cell homeostasis
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- 作者：Lu Chenga ; d ; Huimin Jinb ; Yetao Qiangb ; Shuiyun Wub ; Cheng Yanb ; Mutian Hana ; Tengfei Xiaob ; Nannan Yanb ; Huazhang Ane ; Xiaoming Zhouc ; Qixiang Shaoa ; b ; Sheng Xiaa ; b ; xiasheng1519@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Inflammatory bowel disease ; High fat diet ; Butyrate ; Dendritic cell ; Mucosal immunity ; Retinoic acid
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：1-10
- 全文大小：1843 K
文摘
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High fat diet exacerbated the disease severity of DSS induced colitis.
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Hematopoietic stem/progenitor cells dysregulation were found in HFD/DSS mice.
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HFD promoted the disequilibrium of mucosal dendritic cells.
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Low abundance of butyrate and RA were detected in the gut of HFD mice.