Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses
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- 作者：Di Zhua ; b ; 1 ; Haichang Wanga ; 1 ; Jinglong Zhanga ; 1 ; Xiaotian Zhanga ; Chao Xina ; Fuyang Zhanga ; Yan Leea ; Ling Zhanga ; Kun Liana ; Wenjun Yana ; Xinliang Mac ; Yi Liua ; d ; liuyimeishan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Ling Taoa ; lingtao2006@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Irisin ; Type 2 diabetes ; Endothelium ; Oxidative/nitrative stress
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：87
- 期：Complete
- 页码：138-147
- 全文大小：1304 K
文摘
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Reduced irisin level and impaired endothelial function are seen in T2DM mice.
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Irisin protects endothelial function via reducing oxidative/nitrative stresses.
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Irisin inhibits activation of PKC-β/NADPH oxidase and NF-κB/iNOS pathways.