The Infarct Location Predicts the Outcome of Single Small Subcortical Infarction in the Territory of the Middle Cerebral Artery

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• 作者：Xiaomeng Yang ; MD^&lowast ; ; Yuehua Pu ; MD^&lowast ; ; Liping Liu ; MD^&lowast ; ; Yilong Wang ; MD^&lowast ; ; Xinying Zou ; MD ; PhD^&lowast ; ; Yuesong Pan ; MD^&lowast ; ; Defeng Wang ; PhD^&dagger ; ; Xingquan Zhao ; MD^&lowast ; ; Ka S. Wong ; MD^&Dagger ; ; Yongjun Wang ; MD^&lowast ; ; ^{yongjunwang1962@gmail.com" class="auth_mail}
• 关键词：Single small subcortical infarction ; lesion location ; outcome
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：July 2014
• 年：2014
• 卷：23
• 期：6
• 页码：1676-1681
• 全文大小：381 K

文摘

Single small subcortical infarction (SSSI) in the territory of the middle cerebral artery (MCA) may be classified as proximal SSSI (pSSSI) or distal SSSI (dSSSI) according to its extension to the MCA. We sought to investigate the outcome of different types of SSSIs.

Methods

We assessed 177 patients who had an SSSI (67 pSSSI and 110 dSSSI) in the perforator territory of MCA. The clinical characteristics, neurologic status (initial National Institutes of Health Stroke Scale score at admission and modified Rankin Scale [mRS] score at 1 year), and clinical treatments at 1 year were evaluated.

Results

Among the 177 patients, 130 had favorable (mRS score ≤ 1) and 41 had unfavorable outcome (mRS score ≥ 2) at 1 year, dSSSI had higher mRS than pSSSI at 1 year (1 [0-2] versus 0 [0-1]; P = .013). The age (odds ratio [OR] 1.049, 95% confidence interval [CI] 1.002-1.098; P = .041) and distal location of the lesion (OR 2.687, 95% CI 1.039-6.948; P = .042) were found to be independent risk factors of 1-year unfavorable outcome of SSSIs.

Conclusions

SSSI has a heterogeneous outcome at 1 year according to the lesion location.