Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics
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- 作者：Zhuqing Ouyang1 ; 4 ; Ge Zheng1 ; 4 ; Diana R. Tomchick2 ; Xuelian Luo2 ; 3 ; Hongtao Yu1 ; hongtao.yu@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：62
- 期：2
- 页码：248-259
- 全文大小：3947 K
文摘
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Sororin and Wapl share a previously unidentified YSR motif for Pds5 binding
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Structure of human Pds5B reveals a conserved binding site for the YSR motif
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Inositol hexakisphosphate (IP6) is a structural cofactor of Pds5
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The IP6-binding region of Pds5 binds to Scc1 and inhibits its binding to Smc3