<p id="p0005">3D collagen-based hydrogels and sponge could promote the chondrogenic differentiation of MSCs in vitro.p>
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<p id="p0010">In accordance with the tendency of chondrogenic differentiation, MSCs in 3D scaffolds could secrete various immunoregulatory factors.p>
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<p id="p0015">Scaffold structure could regulate the secretion of soluble immunoregulatory factors to inhibited the activity of allogeneic lymphocytes in a paracrine way.p>
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<p id="p0020">Scaffolds could modulate the immunological properties of allogeneic MSC-derived engineered tissues.p>