Efficacy of a potential DNA vaccine encoding Cryptosporidium baileyi rhomboid protein against homologous challenge in chickens
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- 作者：Yimin Yang ; Xue Xue ; Yi Yang ; Xueqiu Chen ; Aifang Du ; afdu@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cryptosporidium baileyi ; DNA vaccine ; pEGFP-CbROM ; Rhomboid
- 刊名：Veterinary Parasitology
- 出版年：2016
- 出版时间：30 July 2016
- 年：2016
- 卷：225
- 期：Complete
- 页码：5-11
- 全文大小：1201 K
文摘
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Rhomboid gene from Cryptosporidium baileyi is evaluated as a vaccine candidate against cryptosporidiosis.
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This nucleic acid based vaccine can induce antibody responses and peripheral blood T lymphocytes proliferation.
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Immune reactions caused by vaccination exert no obvious effect on the body weight of experimental chickens.
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High dose (100 μg) CbROM gene recombinant DNA in vaccinated chickens conferred certain protective immunity against Cryptosporidium infection.