Multicomponent reaction of pyridine, acetoacetamide/benzoylacetamides and sulfuryl chlorides: regioselective construction of 4-olefinated dihydropyridines

详细信息    查看全文

• 作者：Xuna Zhao ; Tong-Xin Liu ; ^{liutongxin_0912@126.com" class="auth_mail" title="E-mail the corresponding author} ; Nana Ma ; Zhiguo Zhang ; Guisheng Zhang ; ^{zgs6668@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Multicomponent reaction ; N-activated pyridine ; Catalyst-free ; Olefination reaction ; Dihydropyridines
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：11 August 2016
• 年：2016
• 卷：72
• 期：32
• 页码：4938-4946
• 全文大小：766 K

文摘

A new, operationally simple one-pot method has been developed for the regioselective synthesis of a series of novel 4-olefinated dihydropyridines bearing various functional groups from the reaction of pyridine, acylacetamides, and sulfuryl chlorides under mild conditions. In this multicomponent process, subsequent the activation of pyridine by sulfuryl chloride/nucleophilic addition of acylacetonitrile formed in situ/enolization/sulfonylation leads to the formation of final products.