Dry dilute acid pretreatment and biodetoxification are applied on corn stover biorefining. 75.22 g/L of xylonic acid is produced using xylose in cellulosic ethanol distillation stillage. 59.80 g/L of ethanol is also obtained before xylose fermentation. Significant reduction of wastewater generation and energy consumption are achieved. Aspen Plus modeling is conducted on the flowsheet simulation of the proposed process.