Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis

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• 作者：Krist&yacute ; na Kot&yacute ; nková ; ¹ ; ² ; Kuan-Chung Su¹ ; ³ ; Stephen C. West² ; Mark Petronczki¹ ; ⁴ ; ⁵ ; ^{mark_paul.petronczki@boehringer-ingelheim.com}
• 关键词：cytokinesis ; mitosis ; cell division ; plasma membrane ; cytoskeleton ; contractile ring ; cleavage plane ; spindle midzone ; optogenetics ; chemical genetics
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：17
• 期：10
• 页码：2672-2686
• 全文大小：5162 K
• 卷排序：17

文摘

Plasma membrane binding of RhoGEF ECT2 is essential for cytokinesis in human cells ECT2 membrane association at anaphase is required and sufficient for cell division Local optogenetic targeting of ECT2 to the membrane induces unilateral furrows BRCT mutations in ECT2 compromise midzone localization but support cytokinesis