Systematic analysis of key miRNAs and related signaling pathways in colorectal tumorigenesis
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- 作者：Yuan Yina ; 1 ; Mingxu Songa ; 1 ; Bing Gub ; c ; Xiaowei Qid ; Yaling Hua ; Yuyang Fenga ; Heyong Liua ; Leyuan Zhoua ; Zehua Biana ; Jiwei Zhanga ; Xianbo Zuoe ; Zhaohui Huanga ; hzhwxsy@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CRC ; colorectal cancer ; miRNA ; microRNA ; qRT-PCR ; quantificational real-time polymerase chain reaction ; TJP1 ; tight junction protein 1 ; also known as ZO-1
- 刊名：Gene
- 出版年：2016
- 出版时间：10 March 2016
- 年：2016
- 卷：578
- 期：2
- 页码：177-184
- 全文大小：1292 K
文摘
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The miRNA profiling analyses were performed to identify the key miRNAs involved in CRC tumorigenesis.
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Bioinformatics tools were then used to search for the miRNA-targeted signaling pathways.
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To confirm the reliability of the analyses, we identified that ZO-1 is a certain target of miR-212.
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The miRNA regulatory networks associated with colorectal tumorigenesis were established by network analysis.