Surgical resection or additional radiotherapy after superselective intra-arterial chemotherapy (docetaxel, cisplatin, and 5-fluorouracil) using the Seldinger technique and concurrent chemoradiotherapy for T3 or T4 oral squamous cell carcinoma

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• 作者：Yuudai Kondo ; ^{ykonn1218@med.miyazaki-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Kentaro Nagai ; Tomohiro Tamura ; Yuri Tagawa ; Koji Yamamoto ; Yohei Uemura ; Kaori Igawa ; Yoshihiro Yamashita
• 关键词：Chemoradiotherapy ; Concurrent chemoradiotherapy ; Oral squamous cell carcinoma ; Intra-arterial ; Quality of life
• 刊名：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：28
• 期：5
• 页码：385-391
• 全文大小：1984 K

文摘

We report the outcomes of 18 patients with first-onset or previously untreated T3 or T4 oral squamous cell carcinoma (SCC) who received concurrent rapid arterial injection of cisplatin and docetaxel via the femoral artery and intravenous 5-fluorouracil with irradiation (40 Gy), followed by salvage surgery or additional radiation (20 Gy).

Method

They visited our department June 2007–October 2012.

Results

Four (22%) patients achieved complete response (CR). After radiotherapy, the patients with an additional 20 Gy, primary site samples underwent a biopsy. The histopathological score was CR in all 4 patients. Thirteen (72%) patients and 1 (6%) patient achieved a partial response (PR) and no change (NC), respectively. They underwent surgery. As the extent of surgical resection was reset after treatment, it reduced in most of the patients. Seven (50%) patients underwent neck surgery and three patients underwent reconstructive surgery using the pectoralis major myocutaneous flap.

Conclusion

The 3-year survival rate and 3-year local control rate were 94.4% and 100%, respectively.