Exendin-4 antagonizes Aβ1-42-induced suppression of long-term potentiation by regulating intracellular calcium homeostasis in rat hippocampal neurons
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- 作者：Xiaohui Wanga ; 163.wangxh@163.com" class="auth_mail" title="E-mail the corresponding author ; Li Wanga ; Ruirui Jianga ; Yuan Yuanb ; Qianqian Yua ; Yameng Lia
- 关键词：Exendin-4 ; Aβ1-42 ; Neuroprotection ; Calcium homeostasis
- 刊名：Brain Research
- 出版年：2015
- 出版时间：19 November 2015
- 年：2015
- 卷：1627
- 期：Complete
- 页码：101-108
- 全文大小：2461 K
文摘
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Exendin-4 suppressed Aβ-induced [Ca2+]i elevation through L-VDCC and NMDA receptor.
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Exendin-4 antagonized decline of p-CaMKIIα induced by Aβ1-42.
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Exendin-4 is likely to regulate calcium homeostasis to perform neuroprotection.
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The study provides a support for Exendin-4 being used to treat and prevent AD.
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The LTP was investigated with homemade stimulation/recording/drug delivery system.