刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:2017
出版时间:March 2017
年:2017
卷:167
期:Complete
页码:86-97
全文大小:4148 K
卷排序:167
文摘
Hippocampal aromatase and actin polymerization are developmentally regulated. Letrozole inhibits hippocampal actin polymerization in vivo and in vitro. Estradiol rescue LET induced downregulation of actin remodeling proteins. SRC-1 knockdown suppresses E2 induced increased of actin remodeling proteins. Hippocampal E2 regulates actin polymerization in a SRC-1 dependent manner.