One-pot synthesis of 2-aryl-3-alkoxycarbonyl chromones through a cascade Lewis acid-catalyzed aldehyde olefination/oxa-Michael addition/oxidation

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• 作者：Ningning Wang ; Shuying Cai ; Chao Zhou ; Ping Lu ; ^{pinglu@zju.edu.cn} ; Yanguang Wang ; ^{orgwyg@zju.edu.cn}
• 关键词：Chromones ; Heterocycles ; Cycloadditions ; Lewis acid catalysis ; Cascade reactions
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：14 January, 2013
• 年：2013
• 卷：69
• 期：2
• 页码：647-652
• 全文大小：589 K

文摘

2-Aryl-3-alkoxycarbonyl chromones were effectively constructed from aryl aldehydes and 3-(2-(methoxymethoxy)phenyl)propiolates via a cascade Lewis acid catalyzed phenol ether deprotection/aldehyde olefination/intramolecular oxa-Michael addition reaction, and a sequential oxidation. This four-step reaction could be conducted in one-pot with high atom efficiency.