Control-related frontal-striatal function is associated with past suicidal ideation and behavior in patients with recent-onset psychotic major mood disorders
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- 作者：Michael J. Minzenberga ; Michael.minzenberg@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Tyler A. Leshb ; Tara A. Niendamb ; Jong H. Yoond ; Yaoan Chenga ; Remy N. Rhoadesd ; Cameron S. Carterb ; c
- 关键词：Bipolar I disorder ; Major depressive disorder ; Psychosis ; Suicide risk ; Cognitive control ; Frontal cortex
- 刊名：Journal of Affective Disorders
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：188
- 期：Complete
- 页码：202-209
- 全文大小：979 K
文摘
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We evaluated past suicidal ideation and behavior in 30 patients with recent-onset bipolar affective disorder type I or major depressive disorder, each with psychotic features.
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Brain activation during cognitive control task performance was measured by fMRI.
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Past suicidal ideation was associated with control-related activation in right-hemisphere ventral PFC regions, rostral insula, and dorsal striatum.
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Past suicidal behavior was associated with control-related activation in right-hemisphere rostrolateral PFC regions, and relatively lower activity in midline parietal regions.