Synthesis of 1,4-dideoxy-1,4-iminoheptitol and 1,5-dideoxy-1,5-iminooctitols from d-xylose
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- 作者：Amit Kumar ; Mohammed Abrar Alam ; Shikha Rani ; Yashwant D. Vankar
- 关键词：Iminosugars ; Lactol ; Wittig olefination ; Ring closing metathesis ; Dihydroxylation ; d-Xylose
- 刊名：Carbohydrate Research
- 出版年：2010
- 出版时间：16 June 2010
- 年：2010
- 卷：345
- 期：9
- 页码：1142-1148
- 全文大小：544 K
文摘
The synthesis of iminosugars from inexpensive d-xylose in high yields has been developed. The key step in this synthesis involves Wittig olefination or chelation-controlled attack of Grignard reagents on lactol and ring-closing metathesis using first or second generation Grubbs’ catalysts.