Expression and Clinical Significance of the erbB Family in Intrahepatic Cholangiocellular Carcinoma

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• 作者：Yasuhiro Ito ; Yasuhiro Ito ; Tsutomu Takeda ; Yo Sasaki ; Masato Sakon ; Terumasa Yamada ; Shingo Ishiguro ; Shingi Imaoka ; Masahiko Tsujimoto ; Shigeki Higashiyama ; Morito Monden ; Nariaki Matsuura
• 关键词：erbB receptor family ; Cholangiocellular carcinoma ; Immunohistochemistry
• 刊名：Pathology - Research and Practice
• 出版年：2001
• 出版时间：2001
• 年：2001
• 卷：197
• 期：2
• 页码：95-101
• 全文大小：253 K

文摘

The type I family of growth factor receptors is known to play a role in the development of several carcinomas, but its role in hepatic malignancies is not clearly understood. In this study we investigated the expression of this family of EGF-R, c-erbB-2, c-erbB-3 and c-erbB-4 in 38 intrahepatic cholangiocellular carcinomas (CCC) by means of immunohistochemistry. EGF-R expression was related to lymph node metastasis, aberrant p53 expression, proliferating activity, and carcinoma differentiation. c-erbB-2 expression was observed in more than 50 % of the cases, but was not related to any clinicopathological features. c-erbB-3 expression was linked to lymph node metastasis, and c-erbB-4 expression was directly related to proliferating activity and lymph node metastasis. These results indicate that: 1) EGF-R contributes greatly to CCC progression, and c-erbB-3 and c-erbB-4 have roles similar to but less than that of EGF-R, and 2) c-erbB-2 is expressed in CCC in high incidence, but its clinical role in CCC remains unclear.