The Design and Rationale of a Clinical Trial Evaluating Limb Postconditioning in Young Patients with Intracranial Arterial Stenosis

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• 作者：Meng Wei ; MD^* ; Kang Huo ; MD^* ; Rui Liu ; BS^* ; Jian Yang ; MD ; PhD^&dagger ; ; Yawen Cheng ; MD^* ; Sha Chang ; MS^* ; Danfeng Ren ; MS^* ; Guogang Luo ; MD ; PhD^* ; ^{lguogang@163.com" class="auth_mail" title="E-mail the corresponding author} ; ^{67183723@qq.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Upper limb ischemic postconditioning ; symptomatic intracranial atherosclerotic stenosis ; vascular endothelial growth factor ; basic fibroblast growth factor
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：25
• 期：10
• 页码：2506-2512
• 全文大小：713 K

文摘

To examine the effectiveness of bilateral arm remote ischemic postconditioning (RIPC) on the rehabilitation of nerve function and collateral circulation in patients with symptomatic intracranial atherosclerotic stenosis (sICAS).

Setting

Open, controlled, prospective trial (EPIC-sICAS trial) in Xi'an, Shaanxi, China.

Participants

Up to 100 sICAS patients (age: 18-45 years, gender balance) who fulfill the inclusion and exclusion criteria will be enrolled and randomized to intervention group and control group (n ~ 50/group).

Interventions

The intervention group will undergo ischemia and reperfusion on both arms twice a day for 6 months.

Primary and Secondary Outcome Measures

Mean changes in collateral circulation from baseline to the end of the 6-month RIPC treatment period, measured by dynamic contrast-enhanced magnetic resonance imaging, will be the primary outcome. Clinical symptoms, serum levels of vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) will be compared as secondary outcome.

Results

A safety evaluation and preliminary experiment of the EPIC-sICAS trial were completed in November 2014 and March 2015, respectively. Overall and regional brain hemodynamics remained stable throughout RIPC. Activities of daily living score and serum VEGF and bFGF levels were significantly higher (P < .05) in the intervention group.

Conclusions

Repetitive bilateral arm RIPC appears to have protective effects in the brain related to angiogenesis promotion and neuroprotection in the acute phase of sICAS. Assessment of the role of RIPC in collateral circulation requires imaging tests and longer follow-up, as planned in the EPIC-sICAS trial.