Identification of SENP1 inhibitors through in silico screening and rational drug design
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- 作者：Yaxue Zhao ; Zhongli Wang ; Jianchen Zhang ; Huchen Zhou ; hczhou@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：SENP1 inhibitor ; In silico screening ; Rational design ; Cancer
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：178-184
- 全文大小：1270 K
文摘
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Eleven new scaffolds as SENP1 inhibitors discovered through in silico screening.
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New SENP1 inhibitors synthesized and a preliminary SAR discussed.
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Compound 13m showed an IC50 as low as 3.5 μM.