The effect of kyphoscoliosis on intervertebral disc degeneration in dogs

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• 作者：Kiterie Faller ; Jacques Penderis ; Catherine Stalin ; Julien Guevar ; Carmen Yeamans ; Rodrigo Gutierrez-Quintana ; ^{rodrigo.gutierrezquintana@glasgow.ac.uk" class="auth_mail}
• 关键词：Congenital Vertebral Malformation ; Intervertebral Disc Degeneration ; Kyphoscoliosis ; Kyphosis ; Scoliosis
• 刊名：The Veterinary Journal
• 出版年：June 2014
• 年：2014
• 卷：200
• 期：3
• 页码：449-451
• 全文大小：441 K

文摘

In people, abnormalities in vertebral column conformation, such as kyphoscoliosis, induce degenerative changes in adjacent intervertebral disc (IVD) structure and composition. It was hypothesised that canine IVDs adjacent to a vertebral malformation undergo early degeneration.

In a blinded retrospective study, thoracic IVD degeneration was evaluated in 14 dogs on magnetic resonance images using Pfirrmann's grade. IVDs adjacent to a vertebral malformation had higher grades of degeneration than non-adjacent IVDs (P < 0.0001). There was an age-dependency, with dogs between 1 and 4 years showing higher grade of degeneration in adjacent than non-adjacent IVDs (P < 0.0001). Conversely, in older dogs, all IVDs – including the non-adjacents – showed degenerative signs, possibly due to normal aging. These results suggest that congenital vertebral malformation results in early degeneration of adjacent IVDs.