Is hyperbaric oxygen or ozone effective in experimental endocarditis?

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• 作者：Muhammed Turgut Alper Ö ; zkan ; MD^a ; ^{mtaozkan@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Ahmet Vural ; PhD^b ; Ö ; mer Faruk Ç ; iç ; ek ; MD^c ; Ali Ü ; mit Yener ; MD^a ; Sedat Ö ; zcan ; MD^a ; Hü ; seyin Toman ; MD^d ; Ahmet Ü ; nver ; PhD^b ; Mustafa Saç ; ar ; MD^a
• 关键词：Cardiovascular surgery ; Hyperbaric Oxygen ; Ozone ; Linezolide ; Endocarditis
• 刊名：Journal of Surgical Research
• 出版年：2016
• 出版时间：1 May 2016
• 年：2016
• 卷：202
• 期：1
• 页码：66-70
• 全文大小：245 K

文摘

Infective endocarditis, a disease with high mortality and morbidity, is most commonly caused by Staphylococcus aureus; mortality and morbidity further increase in the presence of methicillin-resistant strains of S. aureus. Linezolid is the first of the oxazolidinones, a new antibiotic group that has been approved for the treatment of infections caused by gram-positive cocci. Linezolid reduces the quantity of microorganisms in vegetation to some extent; in addition, the use of hyperbaric oxygen (HBO) and ozone (O₃) therapies is likely to improve targeted antibacterial effect.

Materials and methods

Fifty-six adult male Wistar rats weighing 300–350 g were used. The subjects were divided into groups as follows: Group 1 (n = 8): control group that was not inoculated with microorganisms and was untreated; Group 2 (n = 8): control group that was inoculated with microorganisms but was untreated; Group 3 (n = 8): linezolid treatment group; Group 4 (n = 8): O₃ therapy group; Group 5 (n = 8): HBO therapy group; Group 6 (n = 8): linezolid + O₃ therapy group; Group 7 (n = 8): linezolid + HBO therapy group.

Results

In terms of reducing the number of colonies in the aortic valve, linezolid + HBO therapy was found to be the most effective treatment. Then, respectively linezolid + O₃, linezolid, HBO, and O₃ were found to be effective.

Conclusions

We found that linezolid significantly reduced the number of bacteria in the vegetation in the experimental endocarditis model, and HBO therapy increases the effectiveness of linezolid and makes this better than O₃.