Facile synthesis of the lipid bilayer coated mesoporous silica nanocomposites and their application in drug delivery
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- 作者：Ning Han<sup>asup><sup> ; sup><sup>1sup> ; Yu Wang<sup>bsup><sup> ; sup><sup>1sup> ; Junling Bai<sup>asup> ; Jiangjun Liu<sup>asup> ; Ying Wang<sup>asup> ; Yikun Gao<sup>csup> ; Tongying Jiang<sup>asup> ; Wanjun Kang<sup>bsup> ; Siling Wang<sup>asup><sup> ; sup><sup>silingwang@syphu.edu.cn" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Mesoporous silica ; Lipid bilayer ; Drug delivery ; Cellular uptake ; Biocompatibility
- 刊名：Microporous and Mesoporous Materials
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：219
- 期：Complete
- 页码：209-218
- 全文大小：2143 K
文摘
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The lipid bilayer coated mesoporous silica nanocomposites (LMSNs) were successfully prepared.
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The LMSNs had improved dispersing stability and uptake efficiency compared with bare mesoporous silica nanoparticles (MSNs)
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The presence of the lipid bilayer could improve the biocompatibility and reliability of MSNs as drug carriers.
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The prepared LMSNs can load drug with high efficiency and improve the therapeutic efficacy of the encapsulated drugs.