Corosolic acid plays pro-apoptotic roles in liver cancer cells; Down-regulation of YAP reduces efficacy of Corosolic acid; Corosolic acid-induced degradation of YAP is associated with βTrCP and LATS1; ActinomycinD enhances efficacy of Corosolic acid via YAP and βTrCP; ActinomycinD reduces IC50 value of Corosolic acid in treating liver cancer.