Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells
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- 作者：Xiaoling Guoa ; Deliang Zhua ; Ruiling Lianc ; Yuting Hanc ; Yonglong Guoa ; Zhijie Lib ; Shibo Tangd ; tangsb@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jiansu Chena ; b ; c ; chenjiansu2000@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human retinal pigmented epithelium ; Matrigel ; Activin A ; Cell-cell contact ; Anti-apoptosis
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：37-49
- 全文大小：5987 K
文摘
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The anti-apoptotic activity in hRPE cells was enhanced with Matrigel and Activin A (MA) treatment.
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At the treatment of MA, the tight junctions (TJs) of hRPE cells were maintained very well at least for 4 passages.
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MA treatment could promote TJs and anti-apoptotic activity in hRPE cells, partly involving the Wnt/β-catenin pathway.