Identification of pyrrolo[3,2-c]pyridin-4-amine compounds as a new class of entry inhibitors against influenza viruses in vitro
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- 作者：So Young Chang<sup>asup> ; Deu John M. Cruz<sup>asup><sup> ; sup><sup>1sup> ; Yoonae Ko<sup>bsup> ; Ji-Young Min<sup>asup><sup> ; sup><sup>jiyoung.min@ip-korea.org" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Influenza virus ; Antiviral drugs ; High-throughput screening ; Entry inhibitor ; Pyrrolopyridinamine
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：478
- 期：4
- 页码：1594-1601
- 全文大小：1929 K
文摘
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Four chemical classes are identified from target-focused chemical library by HTS.
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PPA inhibits the infection of various influenza A viruses and influenza B virus.
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PPA is identified to inhibit the early stages of influenza virus infection.
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PPA compound disrupts virus uncoating and nuclear import of viral ribonucleoprotein.