Palladium-catalyzed and copper-mediated cross-coupling reaction of aryl- or alkenylboronic acids with acid chlorides under neutral conditions: efficient synthetic methods for diaryl ketones and chalcones at room temperature

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• 作者：Daisuke Ogawa ; Keita Hyodo ; Masato Suetsugu ; Jing Li ; Yoshiaki Inoue ; Mamoru Fujisawa ; Masayuki Iwasaki ; Kentaro Takagi ; Yasushi Nishihara ; ^{ynishiha@okayama-u.ac.jp}
• 关键词：Palladium ; Copper ; Cross-coupling ; Ketones ; Chalcones
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：25 March, 2013
• 年：2013
• 卷：69
• 期：12
• 页码：2565-2571
• 全文大小：505 K

文摘

Palladium-catalyzed cross-coupling reaction of aryl- or alkenylboronic acids with acid chlorides in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator in diethyl ether at room temperature under strictly non-basic conditions affords the diaryl ketones or chalcones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible.