Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division
详细信息 查看全文
- 作者：Yoshihiro Adachi1 ; Kie Itoh1 ; Tatsuya Yamada1 ; Kara L. Cerveny2 ; Takamichi L. Suzuki1 ; Patrick Macdonald3 ; Michael A. Frohman4 ; Rajesh Ramachandran3 ; Miho Iijima1 ; miijima@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Hiromi Sesaki1 ; 5 ; hsesaki@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：63
- 期：6
- 页码：1034-1043
- 全文大小：3987 K
文摘
- •
Drp1 binds the head group of PA and saturated acyl chains of another phospholipid
- •
The dual lipid interactions restrain Drp1 in mitochondrial division
- •
Drp1 binds a mitochondrial enzyme that produces PA, MitoPLD
- •
MitoPLD creates a PA-rich microenvironment in the vicinity of a division apparatus