Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse

详细信息    查看全文

• 作者：Kitamura ; Yoshihisa ; Ota ; Takashi ; Matsuoka ; Yasuji ; Okazaki ; Mitsuhiro ; Kakimura ; Jun-ichi ; et. al.
• 关键词：p53-deficient mouse ; Kainic acid ; Phosphorylated c-Jun ; Neuronal loss ; Microglia ; Astrocytes ; Hippocampal CA3
• 刊名：Neuroscience Letters
• 出版年：1998
• 出版时间：October 9, 1998
• 年：1998
• 卷：255
• 期：1
• 页码：57-60
• 全文大小：152 K

文摘

We examined kainic acid (KA)-induced neuronal death and changes in glial cells in p53-deficient (p53^−/−) and wild-type (p53^+/+) mice which were CBA and C57BL/6 background. The p53^−/− mouse exhibited a KA-induced loss of CA3 pyramidal neurons similar to that in wild-type mouse. Before neuronal death, c-Jun protein was expressed, phosphorylated and translocated into several nuclei of CA3 pyramidal neurons. In p53^−/− mouse, microglial activation was slightly faster and more continuous after 1–7 days than that in p53^+/+ mouse. On the other hand, p53^−/− astrocytes were relatively resistant to KA cytotoxicity, and marked astrocytosis also occurred after 7 days. These observations suggest that p53-null mutation may influence the activation and proliferation of glial cells rather than neuronal death.