Effects of IL-6, adiponectin, CRP and metabolic syndrome on subclinical atherosclerosis

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• 作者：Makoto Nishida ; Toshiki Moriyama ; Kouki Ishii ; Seiji Takashima ; Kazuyuki Yoshizaki ; Yoshiro Sugita ; Keiko Yamauchi-Takihara
• 关键词：Intima– ; media thickness ; Pulse wave velocity ; Metabolic syndrome ; Inflammation ; Gender
• 刊名：Clinica Chimica Acta
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：384
• 期：1-2
• 页码：99-104
• 全文大小：289 K

文摘

Inflammation has been implicated in the pathogenesis of cardiovascular disease. Since there have been few studies elucidating gender-specific effect of inflammation and metabolic syndrome (MetS) on subclinical atherosclerosis, we evaluated the relative contribution of these factors in healthy subjects.

Methods

MetS components, carotid intima-media thickness (IMT) and pulse wave velocity (PWV) were evaluated in apparently healthy 714 men and 364 women (40–59 y). Serum levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and adiponectin were also examined.

Results

Increase in number of clustering MetS components was more clearly associated with worsening of IMT and PWV in women than in men. Serum IL-6 level was positively correlated with IMT and PWV, and adiponectin level was negatively correlated with IMT in men but not in women. The subjects either with a “high” IL-6 or hs-CRP, or a “low” adiponectin were associated with increase in IMT in the presence of MetS, though there was no significant effect of MetS in those with low inflammation.

Conclusions

While IL-6 and adiponectin are the important risk factors for early arterial alterations in men, components of MetS present profound effects on subclinical atherosclerosis in women rather than in men.