- 作者：Youhua Zhang
- 关键词：Atrioventricular node ; His bundle ; Dual pathway electrophysiology ; His electrogram alternans ; Action potential
- 刊名：International Journal of Cardiology
- 出版年：1 February, 2014
- 年：2014
- 卷：171
- 期：2
- 页码：259-264
- 全文大小：1127 K
Background
We have discovered and validated that AV node dual pathway conduction results in a new phenomenon termed His electrogram alternans (HEA), which indicates dual inputs rather than a final common pathway from the AV node into the His bundle. However, the electrophysiological basis for AV node dual pathway conduction and HEA has not been clarified. This study was designed to elucidate the electrophysiological basis for dual pathway conduction and HEA.Methods
By using HEA as an index of dual pathway electrophysiology, action potentials from multiple locations in the superior and inferior AV nodal domains were obtained to monitor electrical propagation during dual pathway conduction in 8 isolated rabbit hearts.
Results
Fibers inside the AV node were generally aligned along the AV conduction axis. During fast pathway (FP) conduction, electrical excitation in the AV node was propagated in a superior to inferior direction across the major fiber orientation. In contrast, slow pathway (SP) conduction occurred when the superior-inferior propagation failed within the superior nodal domain, permitting electrical propagation to proceed in the inferior nodal domain along the fiber orientation in a posterior to anterior direction. In effect, FP activated first the superior distal node, while SP activated first the inferior distal node. This functional dissociation of superior-fast and inferior-slow domains in distal node produced dual inputs into the His bundle.
Conclusions
Transverse versus longitudinal electrical propagation within the AV node produces functional dissociation in the distal node, resulting in superior-fast and inferior-slow inputs into the His bundle and HEA during dual pathway conduction.